Antibodies are complex molecules produced by the immune system that play a vital role in protecting the human body against diseases and infections. Conventionally, monoclonal antibodies (mAbs) used in medical research were derived from mouse cells. However, in recent years, rabbit monoclonal antibodies (rAb) have emerged as an innovative alternative to traditional mAbs, offering significant advantages in terms of specificity, affinity, and their ability to bind to novel antigens.

Rabbits have a distinct advantage over mice in immunological research because their immune systems can generate more diverse and robust antibody responses. In addition, rabbits can be immunized with smaller amounts of antigen, which minimizes the risk of side effects that may occur when using larger amounts to stimulate the immune response required for antibody production.

Unlike traditional mAbs, rAbs are generated using rabbit B cells, which have a higher affinity for binding to antigens. They are particularly effective in targeting small molecules that cannot be detected by traditional mAbs. Additionally, rAbs offer superior sensitivity and specificity in detecting low-abundance targets such as cancer biomarkers or signaling proteins.

Another benefit of rAbs is their superior stability and longer shelf life compared to traditional mouse-derived mAbs. This makes them more cost-effective, efficient, and easier to store and transport.

The use of rAbs in medical research has opened up many new possibilities, providing researchers with valuable tools to study complex biological processes and identify potential therapeutic targets for diseases such as cancer, autoimmune disorders, and infectious diseases.

One notable example of the success of rAbs is the development of immunotherapy to combat cancer. Immune checkpoint inhibitors, such as PD-L1 antibodies, have been successful in treating a range of cancers. However, due to high levels of variability between patients, some individuals may not respond well to traditional mAbs. Fortunately, rAbs have been shown to have higher affinity and specificity for their target antigen, making them more effective in treating resistant cancers.

In conclusion, rabbit monoclonal antibodies represent an exciting development in medical research, offering numerous advantages over traditional mouse-derived mAbs. Their superior sensitivity, specificity, and stability make them valuable tools for researchers seeking to identify potential therapeutic targets for diseases such as cancer and autoimmune disorders. As a result, they are likely to continue to play a critical role in the future of immunotherapy and medical research.

Here are the best 5 rabbit monoclonal antibody suppliers:

1, Kmdbioscience


In 2014, KMD Bioscience Co., Ltd. was founded in Tianjin, China, with extensive experience developing and researching human medicines. With more than 30 patents and two registered trademarks, KMD Bioscience is a research and development company that provides high-quality products and services to global scientists, research institutes, and pharmaceutical companies. In addition to ISO9001:2015 certifications and national patent pilot laboratory honors, KMD Bioscience is a high-tech enterprise in China. Each year, KMD Bioscience provides over 800 technical service consulting, custom service design, and project delivery services to research institutes, hospitals, pharmaceutical companies, and biological companies.

2, Cellsignal


The Cell Signaling Technology company (CST) is a different type of life sciences organization. It was founded, owned by, and run by scientists who are actively engaged in research. For more than two decades, CST has maintained the highest standards of quality products, services, technological innovation, and scientific rigor. In order to fuel fellow scientists’ quests for discovery, they consistently provide them with best-in-class products and services.

3, Abcam


As a scientific community, they believe that when we work together, they are able to go much farther, much faster. For this reason, they partner with life scientists around the world to develop innovative research solutions for cancer, neurological disorders, infectious diseases and more. Their mission is to help accelerate advances in drug discovery, diagnostics, and basic research in order to help the next breakthrough occur.

4, Prosci-inc


A privately held biotechnology company with over 20 years of experience in San Diego, California, ProSci Incorporated is a leader in the field. ProSci has been a leader in the field for over 20 years and is committed to providing the best products and services for monoclonal, polyclonal, and recombinant antibodies. Providing customized services, innovative products, competitive pricing, high-quality research tools, and unparalleled technical support, ProSci is a leader in antibody development, production, and biological research.

5, Creative-biolabs


Its extensive experience in antibody production and engineering makes Creative Biolabs one of the leading custom service providers. In addition to mouse and rat monoclonal antibody production using hybridoma technology, they also produce monoclonal antibodies for humans, monkeys, rabbits, chickens, dogs, llama and camels using phage display, bacterial display, and yeast display technologies. Using phage display and DNA mutagenesis approaches, they are also experts at conducting in-depth antibody humanization and affinity maturation. Their OEM services are also available at the most competitive prices in the industry for bulk antibody production, including bacterial production of scFv, diabody, tandem scFv, miniantibody, and Fab, as well as mammalian cell expression of minibody, chimeric IgG and IgG.